The GABAa Receptor & Positive Allosteric Modulation

The video tutorial explores the GABA A receptor, highlighting its role in allosteric regulation and its function as a primary inhibitory neurotransmitter in the central nervous system. It explains how GABA binding leads to chloride ion flux and neuron hyperpolarization. The structure of the receptor, including its ionotropic nature and various binding sites, is discussed. The video also covers allosteric modulation, focusing on how positive modulators like benzodiazepines, barbiturates, and ethanol enhance GABA binding and receptor function, leading to sedative effects.

What role do positive allosteric modulators play in the function of the GABA A receptor?

List some common positive allosteric modulators of the GABA A receptor.

How does ethanol act as a positive allosteric modulator of the GABA A receptor?