Regulation of Fatty Acid Metabolism

The video explores the regulation of fatty acid synthesis and its interplay with catabolism, focusing on key enzymes and their control in fed and fasting states. It highlights the role of insulin in activating enzymes during the fed state and the inhibition of these enzymes during fasting or exercise. The video also discusses the importance of acetyl CoA carboxylase as a regulatory point and the mechanisms of hormonal and allosteric regulation.

What are the three major control points in fatty acid synthesis?

How does the Fed state influence fatty acid synthesis?

What role does insulin play in the regulation of citrate lyase?

Explain the significance of acetyl CoA carboxylase in fatty acid synthesis.

Describe the allosteric regulation of acetyl CoA carboxylase.

What happens to fatty acid synthesis during the fasting state?

What mechanisms lead to the inhibition of acetyl CoA carboxylase during fasting?

What are the effects of epinephrine and glucagon on fatty acid metabolism?

Discuss the importance of feedback inhibition in fatty acid synthesis.

How does malonyl CoA affect beta oxidation?