Prions | Mechanisms and Theories of Alzheimers Disease (Amyloid & Tau)

The video explores Alzheimer's disease, focusing on two main hypotheses: the Tau hypothesis and the beta amyloid hypothesis. The Tau hypothesis involves the misfolding of Tau proteins leading to microtubule destabilization and neurofibrillary tangles. The beta amyloid hypothesis involves the formation of amyloid plaques from misfolded beta amyloid proteins, disrupting calcium homeostasis and inducing apoptosis. Both hypotheses contribute to neurodegeneration, with cross-talk between them. Treatments like acetylcholinesterase inhibitors are discussed, though no cure exists.

Discuss the impact of acetylcholine on Alzheimer's disease and its treatment.

What are the main functions of microtubules in healthy neurons?

How does the misfolding of proteins lead to neurodegeneration in Alzheimer's?

What are the potential treatments for Alzheimer's disease mentioned in the text?