Aspartate, Asparagine Biosynthesis

The video explains the biosynthesis of aspartate and asparagine, highlighting their synthesis from the TCA cycle intermediate oxaloacetate. Aspartate is formed through a transamination reaction involving aspartate transaminase, while asparagine is synthesized via asparagine synthetase, using nitrogen from glutamine. The process involves energy generation and recycling of intermediates within the TCA cycle, making aspartate and asparagine non-essential amino acids that can be synthesized de novo.

Explain the difference between the reactions catalyzed by aspartate transaminase and asparagine synthetase.

Why are aspartate and asparagine considered non-essential amino acids?