Glucocorticoids: Mechanisms and Side Effects

The video tutorial explains glucocorticoids, a class of corticosteroids used for their anti-inflammatory and immunosuppressive properties. It covers their endogenous production, synthetic alternatives, and therapeutic applications in conditions like asthma and rheumatoid arthritis. The tutorial delves into the molecular mechanisms of glucocorticoids, including genomic and nongenomic signaling, and highlights their clinical outcomes and potential side effects, such as increased infection risk and Cushing's syndrome. The importance of balancing therapeutic effects with side effects is emphasized.

What are glucocorticoids and what role do they play in inflammation?

Describe the primary functions of glucocorticoids.

What are some common conditions treated with glucocorticoids?

Explain the mechanism of action of glucocorticoids at the cellular level.

What is the significance of the glucocorticoid receptor in the action of glucocorticoids?

How do glucocorticoids influence gene expression?

What are the three mechanisms by which glucocorticoids alter gene expression?

How do glucocorticoids affect the immune response?

Discuss the balance required when using glucocorticoids for treatment.

What are the potential side effects of long-term glucocorticoid use?