Allostery High EC vs Low EC

The video introduces the concept of high and low energy charge, explaining their significance in metabolic pathways and allosteric regulation. It uses practical examples, such as post-meal and fasting states, to illustrate how energy charge affects enzyme activity. The video also provides a detailed example of isocitrate dehydrogenase in the TCA cycle, showing how ATP and ADP regulate its activity.

What are the consequences of having low energy charge in the body?

Explain the role of isocitrate dehydrogenase in the TCA cycle.

How do allosteric activators and inhibitors typically relate to each other?

Discuss the impact of high energy charge on metabolic pathways.