The Mechanism of Insulin Release by Pancreatic β-cells

The video explains how pancreatic beta cells detect blood glucose levels and release insulin to regulate glucose uptake in tissues. It details the role of glucose transporters, ATP production, and the graded response of insulin secretion based on blood glucose levels. The process involves glucokinase and ATP-gated potassium channels, with calcium influx triggering insulin release. The video concludes with a discussion on the graded nature of insulin response and a preview of insulin generation in the Golgi apparatus.

What is the significance of glucokinase in the insulin secretion pathway?

What happens to calcium influx in beta cells when blood glucose levels are low?

Discuss the graded response of insulin secretion to varying blood glucose levels.