Vitamin B9: Folate Activation and Functions

The video tutorial covers the role of folate (vitamin B9) in human metabolism, highlighting its necessity for DNA synthesis and one-carbon metabolism. It discusses the dangers of folate deficiency, particularly during growth and pregnancy, and its link to B12 deficiency. The tutorial explains the conversion of folate to its active form, tetrahydrofolate, and the enzymes involved. It also explores the impact of B12 deficiency on folate metabolism and how folate metabolism is targeted in cancer treatment using drugs like methotrexate and 5-fluorouracil.

Discuss the significance of folate metabolism in cancer treatment.

What is the function of thymidylate synthase in nucleotide synthesis?

What are the potential side effects of targeting folate metabolism in cancer therapy?

How do drugs like methotrexate affect folate metabolism?