Sickle Cell Disease | Pathophysiology, Symptoms and Treatment

The video provides a comprehensive overview of sickle cell disease, a hereditary blood disorder characterized by sickle-shaped red blood cells. It explains the genetic basis, including its incomplete autosomal dominant inheritance, and the prevalence among African Americans. The pathophysiology is detailed, focusing on the mutation in the beta globin chain of hemoglobin. The video also covers the acute and chronic complications, such as anemia and vaso-occlusion, and discusses diagnostic methods and treatments like hydroxyurea and hematopoietic cell transplantation.

What is sickle cell disease and how is it characterized?

Explain the inheritance pattern of sickle cell disease.

What are the differences between homozygous and heterozygous individuals in the context of sickle cell disease?

How does the sickle cell mutation provide protection against malaria?

Describe the pathophysiology of sickle cell disease related to hemoglobin.

What are some acute complications associated with sickle cell disease?

Identify the chronic complications that can arise from sickle cell disease.

What diagnostic tests are used to confirm sickle cell disease?

Discuss the main treatment options available for sickle cell disease.

What role does pain management play in the treatment of sickle cell disease?