Lactic Acidosis: What is it, Causes (ex. metformin), and Subtypes A vs B

The video tutorial explains lactic acidosis, its causes, and subtypes. It begins with defining lactic acidosis and hyperlactatemia, highlighting the importance of distinguishing between them. The tutorial then delves into how lactic acid is produced and cleared in the body, focusing on glucose utilization, alanine deamination, and the Cori cycle. It outlines the pathways of lactic acid production, including glycolysis and the role of lactate dehydrogenase. The causes of lactic acidosis are categorized into increased pyruvate production, impaired mitochondrial utilization, and NADH accumulation. The video also distinguishes between Type A and Type B lactic acidosis, detailing their specific causes, such as hypovolemia, cardiac failure, diabetes, malignancy, and alcoholism.

What role does the liver play in the processing of lactic acid?

How does the Cori cycle relate to lactic acid production?

What are some conditions that can lead to increased production of pyruvate?

List some medications that can lead to type B lactic acidosis.