Organic Chemistry Mechanism Challenge 5

The video tutorial explains a chemical reaction mechanism involving N-butyliithium, TMS CL, and ammonium chloride. It begins with setting up the problem and understanding the reaction conditions. The tutorial then delves into the role of N-butyliithium as a strong nucleophile, attacking the iodo group and forming a negative charge on the SP2 carbon. Next, it covers the interaction of TMS CL with the substrate, leading to the formation of a five-membered ring. Finally, the video describes the deprotection step using ammonium chloride, resulting in the final product. The tutorial emphasizes electron pushing and the energetically favorable pathways in the reaction.

How does the negative charge on the oxygen influence the reaction?

Discuss the role of ammonium chloride in the deprotection step.

What is the final product of the reaction and how is it achieved?