JAK-STAT Signaling Pathway

The video tutorial provides an in-depth overview of the JAK-STAT signaling pathway, explaining its components, including receptors and kinases, and how it operates within cells. It covers the activation process, the role of STAT proteins in transcription, and the pathway's involvement in disease pathogenesis, particularly focusing on mutations that lead to various cancers and blood disorders. The tutorial emphasizes the importance of understanding these mutations for clinical applications.

What are the ligands that activate the receptors in the Jack-Stat signaling pathway?

How does the activation of the Jack-Stat pathway lead to gene transcription?

Explain the significance of the V617F mutation in polycythemia vera.