Regulation of Purine Biosynthesis

The video tutorial explains the regulation of purine synthesis, focusing on key enzymes like PRPP synthetase and glutamine PRPP aminotransferase. It discusses how these enzymes are regulated by energy levels and end products such as AMP, GMP, and IMP. The tutorial also covers feedback inhibition mechanisms in the synthesis pathways of AMP and GMP, highlighting the importance of energy charge and product levels in controlling enzyme activity.

What are the two levels of regulation that occur post-IMP in purine synthesis?

How does the presence of high AMP levels influence the activity of adenylyl succinate synthetase?

Discuss the importance of allosteric regulation in the context of purine synthesis enzymes.