Brain-Derived Neurotrophic Factor (BDNF) | Signaling & Mechanism

The video tutorial explains the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity, focusing on its signaling pathways. It covers the TRKB receptors and their dimerization, leading to three main pathways: AKT, phospholipase C gamma, and MAP kinase. Each pathway contributes to cell survival, growth, and neuroplastic changes, either through gene expression or independent mechanisms. The tutorial also discusses the effects of BDNF, including neurogenesis, synaptogenesis, and synapse strengthening, which are crucial for learning and memory.

What is the role of calmodulin kinase in the signaling pathways activated by BDNF?

Discuss the process of synaptogenesis and its importance in neuroplasticity.

What mechanisms are involved in strengthening synapses as a result of BDNF signaling?

How does BDNF influence neurogenesis?