Ran GTPase Cycle and Nuclear Transport | Importins and Exportins

The video tutorial explains the Ran GTPase cycle, focusing on its role in nuclear transport. It covers the mechanisms of protein transport into and out of the nucleus, highlighting passive diffusion and active transport via importins and exportins. The concept of the Ran gradient is introduced, detailing the forms of Ran protein, Ran GDP, and Ran GTP, and their distribution in the cytosol and nucleus. The processes of nuclear import and export are described, emphasizing the roles of RCC1, Ran GTP, and Ran GDP in facilitating these processes.

How does Ran GTP facilitate the release of cargo proteins from importins?

What happens to Ran GTP when it is hydrolyzed to Ran GDP, and how does this affect export processes?

Discuss the recycling process of Ran GDP back to Ran GTP in the nucleus.