Ras Raf MEK ERK Signaling Pathway - Overview, Regulation and Role in Pathology

The video provides an overview of the Ras RAF MEK Erk pathway, a MAPK cascade crucial for cell proliferation, survival, and metastasis. It explains the roles of Ras, RAF, MEK, and Erk, detailing how the pathway operates and its regulation by factors like EGFR and TGF alpha. The pathway's significance in cancer pathogenesis is highlighted, emphasizing its role in cell proliferation and survival. The video concludes with a promise to explore the pathway's involvement in cancer in future lessons.

What is the Ras RAF MEK Erk pathway and why is it important in certain pathologies?

Describe the role of Ras in the Ras RAF MEK Erk pathway.

What are the main outcomes regulated by Erk in the pathway?

Identify some of the transcription factors activated by Erk and their relevance.

How does EGFR activate Ras in the Ras RAF MEK Erk pathway?

What is the significance of TGF alpha in the regulation of the Ras RAF MEK Erk pathway?

Discuss the complexity of the Ras RAF MEK Erk pathway and its implications in cancer pathogenesis.