Aconitase 1

This video explores the organic mechanism of the enzyme aconitase in the TCA cycle. It details the mechanistic steps, including proton transfer and elimination reactions, and highlights the stereochemical aspects of the reaction, such as anti periplanar orientation and anti addition. The video concludes with the formation of isocitrate, emphasizing its unique stereochemistry.

Discuss the role of water in the aconitase mechanism.

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What does the term 'anti addition' refer to in the context of the hydration step of the aconitase mechanism?

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What is isocitrate and how is it formed in the aconitase reaction?

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