Aminoglycosides | Bacterial Targets, Mechanism of Action, Side Effects

This video lesson covers aminoglycoside antibiotics, focusing on their naming conventions, bacterial targets, clinical applications, mechanism of action, and adverse reactions. Aminoglycosides are used primarily for gram-negative aerobic bacilli and are administered intravenously. They are often combined with other antibiotics for serious infections but can be used alone for tularemia and the plague. The mechanism involves binding to the 30S ribosomal subunit, leading to a bacteriocidal effect. Adverse reactions include ototoxicity and nephrotoxicity, with specific contraindications for patients with neuromuscular disorders.

In what situations are aminoglycosides typically used?

What are the common adverse reactions associated with aminoglycosides?

Why should patients with myasthenia gravis avoid aminoglycosides?