Polycythemia Rubra Vera | Pathophysiology, Symptoms, Diagnosis and Treatment

The video tutorial provides a comprehensive overview of Polycythemia Rubra Vera (PRV), a clonal pluripotent stem cell disorder leading to increased red blood cell production. It covers the pathophysiology, including the JAK2 gene mutation, and its effects on blood volume and viscosity. The tutorial details blood findings, signs, and symptoms such as erythromelalgia and hypertension. It explains the WHO criteria for diagnosis and discusses treatment options like phlebotomy and JAK2 inhibitors.

What role does the Jack 2 mutation play in polycythemia rubra Vera?

How does polycythemia rubra Vera lead to increased blood viscosity?

What is the significance of erythropoietin levels in diagnosing polycythemia rubra Vera?

Explain the treatment options available for polycythemia rubra Vera.