Positive Results from Phase Three Study of Tarceva: A New Approach to Treating Solid Tumors

The video discusses Tarceva, an oral anti-cancer drug that belongs to the class of epidermal growth factor receptor (EGFR) inhibitors. It is in advanced development for non-small cell lung cancer and pancreatic cancer. EGFR is a protein found on many tumor cells, and its overexpression is common in several solid tumors. The international study, conducted by the National Cancer Institute of Canada, focused on overall survival as the primary endpoint. Tarceva shows promise in improving survival and quality of life with fewer side effects compared to chemotherapy. It works by inhibiting receptor tyrosine kinase activity, interfering with cell signaling pathways, and reducing tumor growth. Despite the challenges, EGFR inhibitors are being trialed for difficult-to-treat cancers with high mortality rates.

How does Tarsiva inhibit tumor growth?

Discuss the significance of targeting EGFR in cancer treatment.