Why More Isn’t Always Better For DNA

The video discusses the collaborative efforts of Drs. Harry Orr and Huda Zogby in discovering the genetic basis of SCA One, a neurodegenerative disease. Their work highlights the importance of collaboration over competition in scientific research. They identified the role of CAG repeat expansions in the disease's progression and explored genetic anticipation. Although they have made significant progress in understanding and potentially treating SCA One, challenges remain in translating these findings from mice to humans. Their contributions earned them the 2022 Kavli Prize in Neuroscience.

What were the findings regarding the CAG repeats in the DNA of SCA One patients?

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What progress have Orr and Zogby made in their research 20 years after discovering the genetic root of SCA One?

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How might the discoveries made by Orr and Zogby contribute to future treatments for SCA One?

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