Macroautophagy | Regulation During Feeding, Fasting and Starvation

The video explores how fasting regulates macroautophagy, a process of cellular degradation and recycling. It explains the role of macroautophagy in energy generation during fasting and details the pathway involving autophagosomes and lysosomes. The regulation by mTOR and AMPK is discussed, highlighting their influence on autophagy activation. Nuclear changes during fasting, including the roles of transcription factors like TFEB, ZKSCAN3, and FXR, are covered. The video also touches on the JNK pathway's role in autophagic trafficking. Finally, it summarizes the effects of short-term and prolonged fasting on macroautophagy and chaperone-mediated autophagy.

What is macroautophagy and how does it relate to fasting?

Describe the chronological activation of protein degradation systems during fasting.

What happens to the transcription factor EB (TFEb) during the fed state?

What role do transcriptional repressors like Zach SCAN 3 and FXR play in autophagy regulation?

Explain the role of AMPK in the process of macroautophagy during fasting.

Explain the process of how macroautophagy is activated during fasting.

How does the release of calcium from the lysosome affect autophagy during fasting?

What is the significance of the clear network in relation to TFEb and autophagy?

Discuss the changes in macroautophagy function during short-term versus long-term fasting.

What are the potential consequences of prolonged macroautophagy activation?