Did An Ancient Pathogen Reshape Our Cells?

The video explores the evolutionary history of the sugar molecule alpha gal, which is present in most mammals but absent in catarine primates, including humans. It discusses the hypothesis that a deadly pathogen led to the loss of alpha gal in our ancestors, allowing them to produce antibodies against it. This evolutionary change may have provided a survival advantage against certain pathogens. Modern experiments support this theory, showing that the loss of alpha gal can enhance pathogen resistance but may also lead to reproductive trade-offs.

What is alpha gal and what role does it play in mammalian biology?

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Why did catarine primates, including humans, lose the ability to produce alpha gal?

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What evolutionary advantage might have resulted from the loss of alpha gal in our ancestors?

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How did the presence of a deadly pathogen influence the evolution of alpha gal in primates?

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What implications does the loss of alpha gal have for organ transplants from other mammals?

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What evidence supports the hypothesis regarding the loss of alpha gal in catarine primates?

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Discuss the potential trade-offs associated with the loss of alpha gal in our lineage.

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