Melatonin Catabolism 1

The video tutorial explains the biosynthesis and metabolism of melatonin, highlighting the role of cytochrome P-450 enzymes in drug metabolism. It discusses the function of sulfotransferase and glucuronyl transferase enzymes in increasing molecule polarity for excretion. The tutorial explores melatonin degradation pathways, focusing on the mechanism of sulfotransferase action and its importance in terminating melatonin's effects, such as sleep induction.

What are the pathways for the degradation of melatonin?

What is the role of NADPH in the action of P-450 reductase?

Explain the mechanism of sulfation in the context of melatonin metabolism.

Discuss the importance of terminating the melatonin response in the body.