Biosignaling - Receptor Guanylyl Cyclases & Nitric Oxide

The video tutorial explains the bio signaling pathway involving receptor guanylyl cyclase, focusing on its activation by nitric oxide (NO). It describes two types of guanylyl cyclase: membrane-bound and soluble, with emphasis on the latter's role in smooth muscle relaxation and blood vessel dilation. The tutorial also covers the conversion of GTP to cyclic GMP, which activates protein kinase G, leading to various cellular responses. Additionally, it discusses the role of phosphodiesterase in regulating cyclic GMP levels and how drugs like Viagra inhibit this enzyme to treat conditions like erectile dysfunction.

What is the effect of nitric oxide on blood vessel diameter?

Explain how Viagra works in relation to nitric oxide and cyclic GMP.

Discuss the clinical applications of receptor guanylyl cyclase.