Alternative Pathway of Complement Activation

The video tutorial by Kevin Tolkoff explains the complement activation pathways: classical, lectin, and alternative. The classical pathway requires antibodies, while the lectin pathway is antibody-independent, relying on mannose residues. The alternative pathway is unique, with baseline activity due to C3 hydrolysis. The video details the formation of the membrane attack complex, which disrupts pathogen membranes. The tutorial concludes with a preview of the next video, focusing on the functions of A fragments in the complement system.

What are the main differences between the classical pathway and the lectin pathway of complement activation?

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Explain the role of mannose residues in the lectin pathway.

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Describe the baseline activity of the alternative pathway of complement activation.

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How does protein D interact with hydrolyzed C3 in the alternative pathway?

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What is tickover hydrolysis in the context of complement proteins?

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Discuss the differences in C3 convertase between the alternative pathway and the classical/lectin pathways.

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What is the significance of properdin in the alternative pathway?

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Explain the process of forming a membrane attack complex (MAC) in the complement system.

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How does the alternative pathway differ in its components compared to the classical and lectin pathways?

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What happens to the A components of complement proteins after they are split?

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