Histamine Synthesis and Metabolism Pathway

The video tutorial explains histamine's synthesis and metabolism. Histamine, a biogenic amine, acts as a signaling molecule and neurotransmitter. It is derived from histidine and produced by various cells like mast cells and basophils. The enzyme histidine decarboxylase, with pyridoxal phosphate as a coenzyme, converts histidine to histamine. Histamine is metabolized through pathways involving enzymes like histamine N-methyltransferase and diamine oxidase, leading to excretion in urine. The tutorial concludes with a call to action for viewers to engage with the content.

What is histamine and how is it produced in the body?

Describe the role of histidine in the production of histamine.

What dietary sources provide histidine, and why is it essential for humans?

What is the function of the enzyme histidine decarboxylase in histamine synthesis?

How does the body regulate the activity of histidine decarboxylase?

Explain the metabolic pathways by which histamine is removed from the body.

What are the two main metabolites of histamine and how do they differ?