Plants and Medicine: Aspirin

Aspirin, first identified in plants, is a widely used analgesic, antipyretic, and anti-inflammatory drug. Its origins trace back to ancient Egypt, where Willow bark was used to relieve pain and fever. In 1763, Edward Stone discovered its effects, but it wasn't until the 1900s that Felix Hoffman refined it into acetyl salicylic acid, introducing it as aspirin. Today, aspirin is one of the most commonly used medications, with massive annual production and consumption.

What ancient civilization is credited with the early use of willow bark for pain relief?

Who was the British Reverend that made the connection between willow bark and pain relief?

What significant chemical did Felix Hoffman refine from willow bark?

In what form was acetyl salicylic acid marketed by Hoffman?

Approximately how many metric tons of aspirin are produced and consumed annually?