Hemoglobin Function and Binding Dynamics

The video lecture discusses the oxygen-hemoglobin dissociation curve, explaining the structure of hemoglobin and its role in oxygen transport. It covers glycolysis as the energy source for red blood cells and introduces the concept of cooperativity in hemoglobin binding. The Haldane effect is explained, highlighting the release of CO2 when oxygen binds to hemoglobin. The lecture also explores factors that shift the hemoglobin binding curve, such as pH, temperature, and 2,3-BPG, and their implications for oxygen delivery in different physiological conditions.

What is the primary source of energy for red blood cells?

• Photosynthesis

• Glycolysis

• Fermentation

• Oxidative phosphorylation

How many subunits does a hemoglobin molecule have?

• Three

• Two

• Four

• Five

What is the term used to describe the increased affinity for oxygen binding after the first oxygen molecule binds to hemoglobin?

• Cooperativity

• Competition

• Inhibition

• Saturation

What happens to carbon dioxide when oxygen binds to hemoglobin?

• It is absorbed

• It is released

• It forms carbonic acid

• It remains unchanged

What does a rightward shift in the hemoglobin binding curve indicate?

• No change in oxygen affinity

• Increased oxygen affinity

• Increased carbon dioxide binding

• Decreased oxygen affinity

Which condition is likely to cause a rightward shift in the hemoglobin binding curve?

• Low 2,3-BPG levels

• Low temperature

• High pH

• High carbon dioxide levels

What is the role of 2,3-BPG in oxygen release from hemoglobin?

• It decreases oxygen affinity

• It increases oxygen affinity

• It has no effect

• It binds to oxygen directly

Which of the following is a characteristic of the hemoglobin binding curve in the lungs?

• No shift

• Downward shift

• Leftward shift

• Rightward shift

What effect does fetal hemoglobin have on the oxygen-hemoglobin dissociation curve?

• Shifts it to the right

• Shifts it to the left

• Increases carbon dioxide binding

• No effect

Which factor is NOT associated with a leftward shift in the hemoglobin binding curve?

• Low carbon dioxide levels

• Presence of fetal hemoglobin

• High pH

• High temperature