Immune Cell Markers and Functions

The video tutorial covers various cell surface proteins, focusing on T-cells, B-cells, macrophages, and NK cells. It explains the roles of specific proteins like CD3, CD28, CD4, CD8, and others in immune response. The concept of anergy in T-cells is also discussed, highlighting the importance of co-stimulatory signals for activation.

What is the primary role of the T-cell receptor (TCR)?

• Signal transduction

• Antigen recognition

• Cytokine release

• Co-stimulation

Which protein on T-cells is involved in co-stimulation with B7 on APCs?

• CD28

• CD3

• CD4

• CD8

What is the function of CD40 ligand on helper T-cells?

• Binding to CD40 on B-cells

• Activating cytotoxic T-cells

• Inhibiting immune response

• Recognizing MHC Class I

Which surface marker is used to identify B-cells and is also a receptor for Epstein-Barr virus?

• CD21

• CD19

• CD20

• CD40

What is the primary immunoglobulin expressed on the surface of B-cells?

• IgM

• IgE

• IgD

• IgA

Which marker is specific for macrophages and used for their identification?

• CD14

• CD16

• CD19

• CD56

What is the role of FC receptors on macrophages?

• Inhibiting T-cell activation

• Binding to MHC Class II

• Recognizing opsonized bacteria

• Activating NK cells

Which unique marker is used to identify NK cells?

• CD16

• CD56

• CD8

• CD14

What happens to T-cells in the absence of a co-stimulatory signal?

• They differentiate into B-cells

• They enter a state of anergy

• They undergo apoptosis

• They become hyperactive

Which cells express MHC Class I molecules?

• Only B-cells

• Only macrophages

• Only T-cells

• All nucleated cells