Gas Chromatography Instrumentation Concepts

This video tutorial provides an overview of the Gas Chromatography (GC) instrument, its significance in the pharmaceutical industry, and the importance of regular calibration. It details the main parts of a GC instrument, including the auto sampler, inlet, oven, and detector, and explains the different types of auto samplers and inlets. The video also covers the calibration parameters for each part of the GC instrument, ensuring accurate and reliable analysis.

What is the primary purpose of calibrating a GC instrument?

• To ensure all parts are functioning correctly

• To enhance the speed of analysis

• To reduce the cost of maintenance

• To increase the size of the instrument

What is the main difference between ALS and HSS Auto Samplers?

• HSS is more accurate than ALS

• ALS is faster than HSS

• ALS is used for liquid samples, HSS for vapor samples

• ALS is used for vapor samples, HSS for liquid samples

Which type of column requires the use of a split splitless inlet?

• Neither packed nor capillary columns

• Both packed and capillary columns

• Capillary column

• Packed column

Which part of the GC instrument is responsible for injecting the sample?

• Detector

• Auto Sampler

• Oven

• Inlet

What is the primary function of the GC column oven?

• To cool the sample

• To provide high temperature for analysis

• To store the samples

• To detect the sample components

Which detector is based on flame ionization?

• HSS

• TCD

• FID

• ALS

What is one of the calibration parameters for the ALS?

• Signal to noise

• Drift

• Reproducibility

• Temperature accuracy

Which calibration parameter is common to both the Inlet and the Oven?

• Noise

• Carryover

• Temperature accuracy

• Linearity

What is checked for flow accuracy during GC calibration?

• Auto Sampler

• Carrier gases

• Oven

• Detector

Which tool is generally used to carry out the flow accuracy test for carrier gases?

• Spectrometer

• Thermometer

• Digital flow meter

• Pressure gauge