MHC Complexes and Immune Response

The video discusses the differences between MHC class 1 and class 2 complexes, focusing on their presence in cells, structural differences, interactions with immune cells, genetic encoding, and their roles in graft rejection and antigen clearance. MHC class 1 is present in all nucleated cells and interacts with cytotoxic T cells, while MHC class 2 is found on antigen-presenting cells and interacts with T helper cells. The genetic encoding of these complexes is crucial for organ transplantation success.

What is the primary role of MHC complexes in the immune system?

• To encode DNA sequences

• To present antigens to T cells

• To destroy pathogens directly

• To produce antibodies

Where is MHC Class 1 typically found?

• On non-nucleated cells

• On all nucleated cells

• Only on red blood cells

• Exclusively on B cells

Which cells primarily interact with MHC Class 1?

• Macrophages

• T helper cells

• B cells

• Cytotoxic T cells

On which chromosome is the alpha chain of MHC Class 1 encoded?

• Chromosome 11

• Chromosome 21

• Chromosome 15

• Chromosome 6

Which genes encode MHC Class 2?

• HLA-A, B, C

• HLA-E, F, G

• HLA-H

• HLA-D

What is the main function of MHC Class 2 in the immune response?

• To clear endogenous antigens

• To present exogenous antigens

• To activate B cells directly

• To produce cytokines

How do Tc cells eliminate infected cells?

• By producing antibodies

• By creating pores with perforins

• By engulfing them

• By releasing histamines

Why is MHC compatibility crucial in organ transplantation?

• To ensure faster recovery

• To prevent immune rejection

• To increase blood flow

• To reduce surgical complications

What is the role of T helper cells in relation to MHC Class 2?

• They inhibit immune response

• They produce antibodies

• They destroy infected cells

• They recognize antigens presented by MHC Class 2

What is the significance of MHC proteins being unique to individuals?

• They determine blood type

• They act as DNA fingerprints

• They regulate metabolism

• They control cell division