Lectin Pathway of Complement Activation

The video explains the classical and lectin pathways of complement activation, emphasizing the role of antibodies in the classical pathway and the use of mannose-binding lectin (MBL) in the lectin pathway. MBL binds to sugars on pathogen surfaces, activating MASP, which then splits C4 and C2, leading to the formation of C3 and C5 convertases. This process ultimately results in the formation of the membrane attack complex (MAC), which disrupts the pathogen's membrane. The video also highlights the similarities and differences between the classical and lectin pathways, with a brief mention of the alternative pathway to be covered in a subsequent video.

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