Glycolysis | Regulation of PFK-1/Glycolysis Via PFK-2 Activity

The video explains the regulation of glycolysis and gluconeogenesis through the enzyme phosphofructokinase-1 (PFK-1). It highlights the role of fructose 2,6-bisphosphate as an allosteric activator of PFK-1, influenced by the hormones insulin and glucagon. Insulin promotes glycolysis by activating PFK-2, which increases fructose 2,6-bisphosphate levels, while glucagon favors gluconeogenesis by activating fructose bisphosphatase 2, reducing fructose 2,6-bisphosphate levels. The balance between these hormones determines the metabolic pathway preference, ensuring proper blood glucose regulation.

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