Can Antidepressants Stop Working?

The video addresses a viewer's question about building tolerance to antidepressants, explaining that it can occur in about 25% of people. It discusses the history of antidepressant tolerance, known as 'Prozac poop out,' and explores five reasons for changes in medication response, including generic medication changes, dosage issues, and drug interactions. The video also covers the impact of chronic pain and dopamine depletion on antidepressant efficacy. Finally, it offers strategies to address tolerance, such as adjusting medication dosage or switching medications.

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