Sickle Cell Disease | Pathophysiology, Symptoms and Treatment

The video provides a comprehensive overview of sickle cell disease, a hereditary blood disorder characterized by sickle-shaped red blood cells. It explains the genetic basis, including its incomplete autosomal dominant inheritance, and the prevalence among African Americans. The pathophysiology is detailed, focusing on the mutation in the beta globin chain of hemoglobin. The video also covers the acute and chronic complications, such as anemia and vaso-occlusion, and discusses diagnostic methods and treatments like hydroxyurea and hematopoietic cell transplantation.

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