Chaperone-Mediated Autophagy (CMA) | Selection, Mechanism and Regulation

The video explains chaperone-mediated autophagy (CMA), a selective degradation process targeting proteins with a KFRQ sequence. CMA is activated during prolonged fasting and decreases with aging and certain diets. It involves chaperone proteins like HSC70 and lysosomal proteins such as lamp2A. The process is crucial for cellular health, and its dysfunction is linked to diseases like Danon disease. Lamp2C plays a role in RNA/DNA degradation independently of HSC70. The video concludes with the importance of CMA in maintaining proteostasis.

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