Nucleotide Metabolism | Regulation of Pyrimidine Biosynthesis

The video discusses pyrimidine biosynthesis in both bacteria and humans, focusing on the regulatory differences. In animals, carbamoyl phosphate synthetase is the key regulatory enzyme, activated by PRPP and ATP, and inhibited by UDP and UTP. In bacteria, aspartate transcarbamoylase is the regulatory enzyme, activated by ATP and inhibited by CTP. The regulation ensures a balance between purines and pyrimidines, adapting to the organism's needs.

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