The science behind itch-induced scratching

The study published in Neuron explores a specific category of neurons in the periocodactyl gray area of the brain that tracks itch-induced scratching in mice. Researchers from the Chinese Academy of Sciences examined these neurons in freely moving mice, which were induced to scratch using histamine or chloroquine. The study focused on neurons producing the neurotransmitter tachykinin one, which also produces glutamate and neuropeptides. It was observed that eliminating these neurons reduced itch-induced scratching, while stimulating them caused spontaneous scratching without histamine or chloroquine.

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