Glycolysis and Gluconeogenesis Regulation

The video explains the regulation of glycolysis and gluconeogenesis through fructose 2,6-bisphosphate, a potent allosteric activator of phosphofructokinase-1 (PFK-1). It highlights the hormonal regulation by glucagon and insulin, which influence the levels of fructose 2,6-bisphosphate through a bifunctional enzyme. The phosphorylation state of this enzyme determines whether glycolysis or gluconeogenesis is favored. Real-world examples illustrate how these processes are controlled in response to different metabolic states.

What new insight or understanding did you gain from this video?