Porphobilinogen Synthase: Physiology, Biochemistry, and Organic/Inorganic Mechanism

The video tutorial explores the synthesis of delta aminolevulinic acid in mitochondria and its transport to the cytosol for heme production. It highlights the role of porphobilinogen synthase in converting delta aminolevulinic acid to porphobilinogen, a precursor for heme and other molecules. The enzyme's inhibition by lead and its genetic deficiency, known as aminolevulinic acid dehydratase deficiency or DOS porphyria, are discussed. The video also delves into the enzyme's mechanism, focusing on the role of zinc and lysine residues in the active site.

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