JAK STAT Signaling Pathway: Regulation

The video tutorial explains the JAK-STAT pathway, focusing on its activation by various ligands and the subsequent signaling pathways it triggers, such as PI3K AKT and Ras RAF MEK Erk, which promote cell survival. It also covers the phosphorylation and homodimerization of STAT proteins, leading to gene expression. The tutorial discusses negative regulators like protein tyrosine phosphatases, PIAS, and SOCS, which modulate the pathway's activity. SOCS proteins, in particular, are highlighted for their role in JAK degradation through ubiquitination. The video concludes with a summary and directs viewers to additional resources.

What new insight or understanding did you gain from this video?