Biosignaling | Viagra (Sildenafil) Mechanism of Action

The video explains the action of sildenafil, commonly known as Viagra, initially used as a vasodilator for cardiovascular issues. It details the role of nitric oxide in vasodilation, its interaction with guanylate cyclase, and the production of cyclic GMP. The video further explores how cyclic GMP mediates vasodilation and the role of phosphodiesterase in its degradation, leading to erectile dysfunction. Finally, it describes how sildenafil inhibits phosphodiesterase, maintaining elevated cyclic GMP levels and prolonged vasodilation, aiding in erection maintenance.

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