Progeria, Accelerated Aging | Biochemical Mechanism of Progeria

The video explains progeria, a genetic disease causing accelerated aging, using Sam Burns as a case study. It details the role of lamin A in the nuclear lamina and how its improper processing leads to progeria. The video covers the biosynthetic pathway of lamin A, highlighting post-translational modifications and the consequences of a 50 amino acid deletion in progeria. This deletion results in progerin, which disrupts nuclear structure, leading to DNA damage and cellular senescence, ultimately causing accelerated aging.

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