AMPK Signaling Pathway: Regulation and Downstream Effects

The video provides an overview of the AMPK signaling pathway, highlighting its role as an energy sensor in cells. AMPK is activated by an increased AMP to ATP ratio, exercise, and other factors. Once activated, AMPK regulates various cellular processes, including inhibiting mTOR signaling, promoting autophagy, and affecting protein synthesis. It also influences fatty acid and cholesterol metabolism by activating fatty acid catabolism and inhibiting synthesis. Additionally, AMPK enhances glucose uptake and inhibits glycogen synthesis. Overall, AMPK promotes catabolism over anabolism, aiming to increase energy production and reduce energy expenditure.

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