Covalent Regulation of Glutamine Synthetase

The video explains the covalent regulation of glutamine synthetase, an enzyme that converts glutamate to glutamine. This regulation is crucial due to the enzyme's interaction with toxic ammonia. The enzyme is regulated by adenylation and deadenylation, controlled by adenyl transferase and uridyl transferase. High energy states activate glutamine synthetase, promoting biosynthesis, while low energy states favor catabolism. The video also highlights the role of P2 protein in this regulatory mechanism.

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