Pyruvate Dehydrogenase: Covalent Regulation

The video explains the covalent regulation of the pyruvate dehydrogenase complex, a key enzyme linking glycolysis and the TCA cycle. It discusses how pyruvate is converted to acetyl CoA, the importance of regulating this enzyme due to its role in various metabolic pathways, and the mechanisms of covalent regulation through phosphorylation. The video also covers higher-level regulation involving allosteric control by molecules like ATP and NADH, and the role of calcium in activating the enzyme.

What new insight or understanding did you gain from this video?