Porphobilinogen Deaminase: Physiology, Biochemistry, and Organic Mechanism

The video explores the intricate process of heme synthesis, focusing on the enzyme porphobilinogen deaminase. It explains the enzyme's mechanism, including the rare E1 mechanism, and the synthesis of hydroxymethyl bilane. The video also covers the subcellular compartments involved in heme synthesis and the energetic demands of the process. Additionally, it discusses the implications of enzyme deficiencies, particularly acute intermittent porphyria, and the accumulation of porphobilinogen in the cytosol.

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