Huntington's Disease (RE-UPLOAD) | Pathogenesis, Signs/Symptoms, and Detailed Mechanism

The video provides an in-depth look at Huntington's disease, starting with its pathophysiology and the role of the Huntington protein. It explains how genetic variations in the number of CAG repeats can affect the onset and severity of the disease. The video details how misfolded proteins lead to neuron degeneration, particularly in the basal nuclei, causing symptoms like chorea. It reviews the direct and indirect pathways of the basal nuclei and how Huntington's disease disrupts these pathways, leading to increased movement and muscle contraction.

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