Aldehyde Dehydrogenase 1

The video tutorial explores the mechanism of aldehyde dehydrogenases, enzymes crucial in amino acid catabolism and ethanol metabolism. It details the steps of the mechanism, including nucleophilic attack, intermediate formation, and hydrolysis, highlighting the role of cysteine thiolate and glutamate. The tutorial also discusses the generation of reduced cofactors NADH or NADPH and mentions inferred steps in the mechanism. Variations with different nucleophiles, such as phosphate, are also covered.

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